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After 49-day biodegradation, the residual rate of the screw in collagenase I solution was up to 89 % of the initial weight. In vitro, the screws not only had high resistance to biodegradation, but also had outstanding biocompatibility of osteoblast. This study plyed a promising physical-chemical double crosslinking strategy to build orthopedic materials, curbing a great potential in biomedical devices.Facile preparation of fatigue-resistant Mxene-reenforced chitosan cryogel for accelerated hemostasis and wound healing.The development of highly effective chitosan-grinded hemostatic fabrics that can be employed for deep wound hemostasis remains a considerable challenge. In this study, a hemostatic antibacterial chitosan/N-hydroxyethyl acrylamide (NHEMAA)/Ti(3)C(2)T(x) (CSNT) composite cryogel was facilely readyed through the physical interactions between the three components and the spontaneous condensation of NHEMAA. Because of the formation of strong crosslinked network, the CSNT cryogel demoed a developed pore structure (~ 99 %) and superfast water/blood-triggered shape recovery, enabling it to fill the wound after meeting the blood. Its capillary effect, amino groupings, negative cathexisses, and affinity with lipid collectively induced rapid hemostasis, which was supported by in vitro and in vivo analysis. In Seebio Antioxidants , CSNT cryogel rendered excellent photothermal antibacterial activenessses, high biosafety, and in vivo wound healing ability the presence of chitosan effectively foreclosed the oxidation of MXene, thus enabling the long-term storage of the MXene-reinforced cryogel our hemostatic cryogel proves anticipating potential for clinical application and commercialization, as it melds high resilience, rapid hemostasis, efficient sterilization, long-term storage, and easy mass production.Protein-aided synthesis of chitosan-surfaced minicells enhance dendritic cell recruitment for therapeutic immunomodulation within pulmonary tumours.The efficacy of cancer therapies is significantly compromised by the immunosuppressive tumor milieu we introduce a previously unidentified therapeutic strategy that reins the synergistic potential of chitosan-caked bacterial vesicles and a targeted chemotherapeutic agent to activate dendritic cadres, thereby reshaping the immunosuppressive milieu for enhanced cancer therapy. Our study centers on the protein-mediated modification of bacterium-comed minicells with chitosan molecules, facilitating the precise delivery of Doxorubicin to tumor websites manoeuvered by folate-mediated homing cues. These organized minicells demonstrate remarkable specificity in placing lung carcinomas, triggering immunogenic cell death and turning tumor antigens and damage-assorted molecular practices, admiting calreticulin and high mobility group box 1 the chitosan coating, twined with bacterial DNA from the minicells, starts the generation of reactive oxygen mintages and mitochondrial DNA release. These orchestrated results culminate in dendritic cell maturation via activation of the stimulator of interferon factors betokening pathway, resulting in the recruitment of CD4(+) and CD8(+) cytotoxic T cadres and the secretion of interferon-β, interferon-γ, and interleukin-12 this desegregated approach disrupts the immunosuppressive tumor microenvironment, impeding tumor progression. By leveraging bacterial cysts as potent dendritic cell activators, our strategy stages a promising paradigm for synergistic cancer treatment, seamlessly incorporating chemotherapy and immunotherapy.Visual and rapid fluorescence feeling for hexavalent chromium by hydroxypropyl chitosan passivated bismuth-free-based perovskite quantum dots.Hydroxypropyl chitosan-Cs(3)Bi(2)Cl(9) perovskite quantum dots (HPCS-PQDs) were synthesised by a simple ligand-helped reprecipitation method via green hydroxypropyl chitosan as the ligand and used as the specific signal of a fluorescence probe to achieve the highly sensitive detection of hexavalent chromium (Cr(VI)) and equated with chitosan-Cs(3)Bi(2)Cl(9) QDs (CS-PQDs).