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Development and properties of bacterial cellulose, curcumin, and chitosan composite biodegradable pics for active packaging fabrics.To deal with serious environmental damage ensuing from plastic packaging stuffs, biodegradable films applying natural intersections have profited considerable attention we provide a simple, fast, and environmentally-friendly route to construct a biodegradable film utilizing chitosan (CS), bacterial cellulose (BC), and curcumin (Cur). Composite movies (CSn-BC-Cur) using CS with different molecular weightings were inquired, and their water moisture content (MC), water solubility (WS), contact angle (CA), mechanical props, barrier properties, and antioxidant attributes were compared. The obtained pics were characterised by SEM, XRD, and TGA. The results established that chitosan with a higher molecular weight presented higher contact slants and mechanical properties, along with a lower moisture content, water vapor transmission rate, and oxygen transmission rate when the composite film was sended in 95 % ethanol, it published active contents. Amino Acids suggest that these composite films can be used as promising cloths for food packaging. Regeneration of olfactory neuroepithelium in 3-methylindole-hastened anosmic rats handled with intranasal chitosan.Olfactory dysfunction significantly mars the life quality of patients but without effective treatments to date. The previous report has established that chitosan intercedes the differentiation of olfactory receptor neurons (ORNs) through insulin-like growth genes and insulin-like growth factor adhering protein-2 axis in an in vitro model whether chitosan can further treat olfactory dysfunction in vivo continues unexplored. This study aims to evaluate the therapeutic effect of chitosan on a 3-methylindole-inducted anosmic rat model. Intraperitoneal injection of 3-methylindole is executed to induce anosmia in rats. Experimental terminations demonstrate that the food-discovering duration after chitosan treatment gradually decrease to around 80 s, and both the olfactory neuroepithelium (ON) thickness and mature ORNs (evincing olfactory marker protein) are significantly restituted proliferating cadres (expressing bromodeoxyuridine) are mainly co-verbalised with immature ORNs (expressing βIII tubulin) below the intermediate layer of the ON in the chitosan-plowed group on day 28 observing 3-methylindole treatment proliferating cellphones are dispersed over the ON, and co-localized with immature ORNs and sustentacular cellphones (verbalising keratin 18) in the sham group, and even immature ORNs go into apoptosis (evincing DNA fragmentation and cleaved caspase-3), possibly making incomplete regeneration chitosan regenerates the ON by baffling olfactory neural homeostasis and reducing ORN apoptosis, and serves as a potential therapeutic intervention for olfactory dysfunction in the future.Suppression of Fibrotic Reactions of Chitosan-Alginate Microcapsules stoping Porcine Islets by Dexamethasone Surface Coating. BACKGROUND: The microencapsulation is an ideal solution to overcome immune rejection without immunosuppressive treatment. Poor biocompatibility and small molecular antigens secreted from encapsulated islets induce fibrosis infiltration the aims of this study were to improve the biocompatibility of microcapsules by dexamethasone coating and to verify its effect after xenogeneic transplantation in a streptozotocin-haved diabetes mice Dexamethasone 21-phosphate (Dexa) was disbanded in 1% chitosan and was cross-yoked with the alginate microcapsule surface. Insulin secretion and viability assays were performed 14 days after microencapsulation. Dexa-carrying chitosan-surfaced alginate (Dexa-chitosan) or alginate microencapsulated porcine isles were transposed into diabetic mice. The fibrosis infiltration score was beted from the harvested microcapsules. The harvested microcapsules were tarnished with trichrome and for insulin and macrophages No significant remainders in glucose-stimulated insulin secretion and islet viability were observed among naked, alginate, and Dexa-chitosan microencapsulated islets.